-1 - Enhancement of Human Cancer Cell Motility and Invasiveness by Anaphylatoxin C5a via Aberrantly Expressed C5a-receptor (cd88)

نویسندگان

  • Hidetoshi Nitta
  • Yoshihiro Wada
  • Yoshiaki Kawano
  • Yoji Murakami
  • Atsushi Irie
  • Keisuke Taniguchi
  • Ken Kikuchi
  • Gen Yamada
  • Kentaro Suzuki
  • Jiro Honda
  • Masayo Wilson-Morifuji
  • Norie Araki
  • Masatoshi Eto
  • Hideo Baba
  • Takahisa Imamura
  • T. Imamura
چکیده

* these authors contributed equally to this work Department of Molecular Pathology, Department of Gastroenterological Surgery, Department of Urology, Department of Immunogenetics, Department of Tumor Genetics and Biology, Faculty of Life Sciences, Kumamoto University, Medical Quality Management Center, Kumamoto University Hospital, and Department of Pharmacology, Mitsubishi Chemical Medience Corporation, Kumamoto, and Department of Genetics, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Enhancement of human cancer cell motility and invasiveness by anaphylatoxin C5a via aberrantly expressed C5a receptor (CD88).

PURPOSE The anaphylatoxin C5a is a chemoattractant that induces leukocyte migration via C5a receptor (C5aR). There is emerging evidence that C5a is generated in the cancer microenvironment. We therefore sought C5aR expression and a direct influence of the C5a-C5aR axis on cancer cells. EXPERIMENTAL DESIGN C5aR expression was investigated in human cancer tissues and cell lines. Effects of C5a ...

متن کامل

Human Cancer Biology Enhancement of Human Cancer Cell Motility and Invasiveness by Anaphylatoxin C5a via Aberrantly Expressed C5a Receptor (CD88)

Purpose: The anaphylatoxin C5a is a chemoattractant that induces leukocyte migration via C5a receptor (C5aR). There is emerging evidence that C5a is generated in the cancer microenvironment. We therefore sought C5aR expression and a direct influence of the C5a–C5aR axis on cancer cells. ExperimentalDesign:C5aR expressionwas investigated in human cancer tissues and cell lines. Effects of C5a sti...

متن کامل

Cancer cells release anaphylatoxin C5a from C5 by serine protease to enhance invasiveness.

Anaphylatoxin C5a indirectly fosters cancer cells through recruitment of myeloid-derived suppressor cells (MDS) for inhibiting antitumor CD8+ T cells and induction of neovascularization. We recently found activation of cancer cells by C5a directly via the C5a-receptor (C5aR; CD88) to enhance invasiveness. Thus, C5a possibly contributes to cancer progression rather than elimination. C5a generati...

متن کامل

C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism.

The anaphylatoxin C5a exerts a plethora of biologic activities critical in the pathogenesis of systemic inflammatory diseases. Recently, we reported on a C5a mutant, jun/fos-A8, as a potent antagonist for the human and mouse C5a receptor (CD88). Addressing the molecular mechanism accounting for CD88 receptor antagonism by site-directed mutagenesis, we found that a positively charged amino acid ...

متن کامل

Human Mesangial Cells Receptors for the Anaphylatoxin C5a (CD88) on

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012